POST-DOCTORAL POSITION IN HEMATOPOIETIC STEM CELL BIOLOGY- FONTENAY-AUX-ROSES, FRANCE

Employer
Inserm
Location
France
Posted
March 01 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

A 18 months postdoctoral position is available under the supervision of Dr Marie-Laure Arcangeli in the Laboratory of Hematopoietic Stem cells and Leukemia headed by Dr Françoise PFLUMIO, in Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France.

The position is funded by Cancéropôle Ile-de-France (net monthly salary: 2100 Euros) and will start between March and June 2017. We are expecting a highly motivated scientist to join an ongoing research program focused on the mechanisms involved in the control of hematopoietic stem cell (HSC) quiescence and self-renewal. Briefly, we are currently studying the effects of genotoxic stress on HSC maintenance using HSC exposition to low doses of ionizing radiations (manuscript in preparation) and models of mice deficient for proteins involved in stress responses.


The applicant has recently defended a PhD in Hematology or Immunology and has not yet been elected for any research contract after the PhD thesis. Applicants with a post-doc position after the PhD defense are not eligible.


The applicant must have a solid experience in experimental hematopoiesis (human and/or murine) and multi-parametric flow cytometry. Propensity to work with mice is mandatory. Strong background in malignant hematopoiesis would be greatly appreciated. The applicant will have a complementary training in relevant disciplines related to hematology/immunology (cellular biology, imaging, biochemistry...).


The laboratory is located in the suburb of Paris, easily accessible by public transportation. The scientific environment and the Institute provide state of the art facilities to carry out in vivo and in vitro studies as well as molecular/cellular studies. Applications, including a cover letter giving a brief description of the previous experience, a CV + List of publications, and names/e-mail addresses of at least two referent persons who could provide recommendation letters, need to be sent to:


Dr Marie-Laure Arcangeli, Ph.D.

email : marie-laure.arcangeli@inserm.fr ou marie-laure.arcangeli@cea.fr


LSHL-iRCM-CEA-INSERM UMR967

18 route du panorama

Bat05 2ème étage pièce A203

92260 Fontenay-aux-Roses The research is program focused on the mechanisms involved in the control of hematopoietic stem cell (HSC) quiescence and self-renewal.


1Arcangeli, ML et al. JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Blood 118 (2011)

2Arcangeli, ML et al. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. Stem Cells 32 (2014)

3Reynaud, D. et al. SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood 106 (2005).

4Benyoucef, A. et al. The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells. Stem cells 33 (2015).

5Correia NC*, Arcangeli ML*, Pflumio F, Barata JT. Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage. Leukemia 30 (2016)* co-first authors

6Mantel, C. R. et al. Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock. Cell 161 (2015).

7Lo Celso, C. & Scadden, D. T. The haematopoietic stem cell niche at a glance. Journal of cell science 124, (2011).

8Pouzolles, M., Oburoglu, L., Taylor, N. & Zimmermann, V. S. Hematopoietic stem cell lineage specification. Current opinion in hematology 23 (2016).

9Suda, T., Takubo, K. & Semenza, G. L. Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell stem cell 9 (2011).

10Notta, F. et al. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science 333 (2011).



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