Postdoctoral Fellow - Cancer Research
The laboratory investigates the biology, properties and clinical utilities of Circulating Tumor Cells (CTCs) – “seeds” of fatal metastatic disease which is the major cause of cancer patients’ mortality. CTCs are proving to be viable diagnostic tools for noninvasive real-time assessment of cancer progression (“liquid biopsy”). Evaluation of CTCs may enable a more sensitive monitoring of treatment efficacy, thus guiding drug selection in adjuvant settings where no such tools exist today. However, current technologies prevent researchers from identifying the majority of the CTCs from cancer patients that spread (metastasize) within the body, notably to brain. Brain metastasis represents an urgent clinical problem which is increasing in frequency with dismal patient survival rates.
Dr. Marchetti and team are working to develop a vigorous biomarker program with Houston Methodist Hospital faculty across numerous disciplines with a primary focus on breast cancer brain metastasis. One of his main priorities is to better understand why breast cancer reoccurs and how to decipher the molecular heterogeneity of CTC subset phenotypes responsible for seeding/reseeding metastases and leading to patients’ death.
Dr. Marchetti is an internationally recognized expert and authority in the field of circulating tumor cells (CTCs) CTCs can be clinically useful tools to combat cancer metastasis for improved patient outcome, prime examples of precision medicine. With keen insights into the biology of brain metastasis, he pioneered models discovering molecular determinants underlying brain metastasis and biomarker properties of brain-homing CTCs.
DUTIES AND RESPONSIBILITIES
- Develops research methods and performs research activities. (EF)
- Documents research results and writes reports of results for presentation and/or publication in professional journals and other publications. (EF)
- Assists in maintaining the functionality and operations of the Principal Investigator’s laboratory. (EF)
- Demonstrates the components of the I CARE values. (EF)
- Follows all safety rules while on the job. Reports accidents promptly and corrects minor safety hazards. Communicates with peers and management regarding any hazards identified in the workplace. (EF)
- Performs other duties as assigned by the Principal Investigator.
- A strong laboratory experience with a profound knowledge and experience with cutting-edge molecular biology technologies, experimental animal proficiency (eg, tumor cell injections in mice), bio-imaging, and strong abilities to work independently and with self-initiative.
- Abilities to vigorously pursue scientific projects, both conceptually and experimentally, with pro-active thinking and action;
- An inner motivation to succeed in a highly focused scientific environment.
M.D. or Ph.D required
**Please send inquiries to Dr. D. Marchetti at: email@example.com
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