A position is available in the laboratory of Jae-Won Shin, Ph.D., for a highly motivated postdoctoral fellow to work in an interdisciplinary research environment at the interface between medical science and engineering.
The postdoctoral fellow will work on integrative approaches to investigate how biophysical forces, such as fluid shear and matrix mechanics impact stem cell functions in the hematopoietic system and other systems derived from the mesoderm. To both manipulate and measure physical forces exerted on cells, we use various microtechnologies, including micropipetting, atomic force microscopy, and microfluidics. These methods are used in combination with molecular biology and protein biochemistry to reveal mechanobiological circuits underlying force-dependent regulation of stem cell trafficking and soluble factor secretions. Fundamental insights from these efforts are aimed at developing biomaterial-based translational applications for blood and immune diseases by designing stem cell therapy products ex vivo, controlling cell delivery in vivo, and targeting cells in situ.
The Principal Investigator will help the applicant develop his/her career by providing a dynamic and collaborative research environment. The PI will encourage the preparation of research papers, application of fellowships, and presentation at national/international meetings.
For access to full-length publications from Dr. Shin, please visit:
The postdoctoral fellow is expected to develop and learn to utilize various techniques in both biological (e.g. molecular biology and protein biochemistry) and physical sciences (e.g. atomic force microscopy, micropipetting, biomaterial design, and microfabrication). To facilitate this effort, the fellow will have an access to various state-of-the-art facilities in the University of Illinois at Chicago campus (http://www.rrc.uic.edu), and other major institutions in the Chicago area through the Chicago Biomedical Consortium (http://www.chicagobiomedicalconsortium.org).
1) Candidates must have a Ph.D. or M.D./Ph.D. degree.
2) Expertise in at least two of the following areas:
- Polymer chemistry to design biomaterials, including nanoparticles and hydrogels
- Manipulation and measurement at micro and nanoscales: e.g. microfluidics, microfabrication, micropipetting, and atomic force microscopy
- In vivo animal studies (rodents): e.g. breeding, transplantation, survival surgery, and in vivo imaging
- Molecular biology and engineering: e.g. cloning, mutagenesis, gene editing, gene delivery, and qPCR
- Protein biochemistry: e.g. western blotting, recombinant protein production, and mass spectrometry
- Cell biology and engineering: e.g. primary cell isolation, FACS, 3D cell culture, confocal microscopy, and cell surface engineering
3) Minimum of one first author papers in international journals
4) Excellent verbal and written communication skills in English.
Interested applicants who meet all the criteria above should send a PDF file which includes a cover letter stating career goals, CV, and contact information (including email addresses and phone numbers) for three references to Jae-Won Shin, Ph.D. Email to: email@example.com