Postdoctoral Position in Pancreatic Cancer Biology and Experimental Therapeutics
The Edwin L. Steele Laboratory (Massachusetts General Hospital, Harvard Medical School) is committed to improving the detection and treatment of cancer through a better understanding of tumor pathophysiology, angiogenesis, lymphangiogenesis and transport barriers within tumors.
POSITION AVAILABLE FOR THE FOLLOWING PROJECT:
The collagen-rich desmoplasia in pancreatic cancer reduces vascular perfusion and the delivery and effectiveness of cytotoxic agents. The interaction between cancer cells, macrophages and pancreatic stellate cells (PSCs) plays a major role in the development of desmoplasia. The candidate will test if the targeting of macrophage subpopulations and PSCs reduces desmoplasia and improves drug delivery and effectiveness in pancreatic cancer. In vivo imaging approaches will be used to measure collagen production and degradation, and changes in vascular architecture and blood flow. To establish how the targeting of macrophages and PSCs affect gene expression transcriptome analyses will be performed.
The candidate must have experience in macrophage or fibroblast biology. A strong background and previous experience in the synthesis or degradation of extracellular matrix, drug delivery, transgenic mouse models of primary and metastatic pancreatic cancer and transcriptome analysis will be a plus. The successful candidate must have outstanding achievements in their doctoral or postdoctoral research and possess independent research abilities and ambitious scientific goals.
Please send a cover letter describing your experience and a single PDF with CV, names of three references, and a cover letter describing your specific experience and interests to Dr Yves Boucher (email@example.com).